About the Webinar

Solar lentigo (SL) is one of the most conspicuous skin concerns in photoaging. It is caused by chronic UV exposure, which leads to hyperpigmentation. One of the biggest challenges of SL research is to obtain live skin tissues to understand dynamics of its cellular microenvironment. To overcome the problem, we aimed to develop a non-invasive measurement technique for SL at the cellular level by revealing a key microenvironment of SL. Measurement of NAD(P)H fluorescent lifetime decay by fluorescence lifetime microscopy, FLIM, indicated that oxidative-phosphorylation (OXPHOS) activity of mitochondria was downregulated in SL. Excessive melanin-deposition caused OXPHOS downregulation and induced senescence phenotypes by arresting cell cycle and increasing SASPs. An active ingredient complex significantly improved OXPHOS downregulation in SL and prevented the senescence phenotypes induced by excessive melanin in vitro. Our results suggest an excessive melanin-dependent senescence process and provide the pragmatic solution improving the deteriorated microenvironment of SL.
 

About the Speaker:

After receiving his PhD in Developmental and Cell Biology from Kyushu University in Japan, Dr. Daigo Inoue began his career as a postdoctoral researcher at the European Molecular Biology Laboratory (EMBL) in Germany in 2009. There, he investigated the dynamics of embryonic development using the Japanese killifish, medaka. As a recipient of the prestigious Human Frontier Science Program (HFSP) long-term fellowship for overseas research, he led his own projects for over eight years.

In 2017, Dr. Inoue joined Shiseido Co., Ltd. to explore new frontiers in dermatology, with a particular focus on the enigma of solar lentigo (dark spot) formation. Since then, he has been deeply engaged in studying the parallels between skin homeostasis and embryonic development, where the underlying molecular mechanisms of cellular dynamics play a crucial role, even within the age-spot-specific microenvironment.

In 2024, Dr. Inoue was awarded with the 2024 Basic Research Award for his work at the IFSCC Congress in Iguazu Falls, Brazil.